In my experience, blockmixing hurts performance about as much as using normal, non-mixed blocks. You'll really only run into trouble if you use an absurd amount of them, but even then I find that you're usually okay. One crash shouldn't be anything to worry too much about; that could be an MP problem unrelated to blockmixing entirely. If you're consistently crashing on your complex map, then there might be a problem with them, but as it stands right now it sounds like you're fine.